Store intact vials at room temp or under refrigeration. Ifosfamide is given intravenously by iv usually once a day for five days every three weeks. Risk factors for the development of cns toxicity include the following. Interactive learning, teaching and evaluation resources created with geogebra can be shared and used by everyone at the geogebra app for powerpoint lets you insert interactive geogebra materials into your presentation. Aug, 2018 drinking alcohol can increase certain side effects of ifosfamide, especially nausea and vomiting. Open your powerpoint presentation on the page you want to insert the pdf within. Carcinogenesis, mutagenesis, impairment of fertility. Ixempra ixabepilone dosing and administration guide. Ifosfamide is a synthetic structural isomer of cyclophosphamide that has been approved for concurrent use with other drugs usually cisplatin, etoposide, or vinblastine in the treatment of metastatic germcell testicular cancer and some especially pediatric sarcomas. Mesnex is indicated as a prophylactic agent in reducing the. Learn how to insert objects in microsoft powerpoint at get the complete tutorial free.
Ifosfamide, like cyclophosphamide, is an oxazophosphorine alkylating agent. Ifex ifosfamide for injection singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. How to convert powerpoint into an interactive elearning. Ifosfamide has been shown to be carcinogenic in rats, with female rats showing a significant. Ifex ifosfamide dose, indications, adverse effects.
Ifosfamide is a widely used antitumour agent, and concentrations measured in the hospital effluent, sewage treatment plant influent, and effluent were almost the same, indicating that no adsorption, biodegradation, or elimination of it took place kummerer et al. The total daily dose of mesnex is 100% of the ifosfamide dose. Ten to 15% of patients treated with ifosfamide develop an encephalopathy. Breastfeeding is not recommended as the drug is distributed into breast. Studies of ifosfamide injection in patients with hepatic or renal impairment have not been conducted see use in specific populations 8. Ifosfamide fda prescribing information, side effects and uses. Activation occurs by hydroxylation at the ring carbon.
Because of the potential for serious adverse events and the tumorigenicity shown for ifosfamide in animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. The recommended dosing schedule is outlined below in table 1. Ifosfamide for injection ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Ifosfamide is used in the treatment of sarcomas and other tumors. To keep a pdf file as a support document for your presentation insert the entire pdf into the presentation as an object that you can open and view during your presentation. Adjust dose accordingly if ifosfamide dose changes. Any changes you make to these geogebra materials are saved in your powerpoint file. However, as this emedtv segment explains, your ifosfamide dosage will be calculated using your weight, height, and other medical conditions, among other factors. Antineoplastic drug traces are found on the exterior surface of vials and on many.
Voorma, ingevolge het besluit van het college voor promoties. Apparently, when rendering the pdf into a bitmap for printingscreen. Unfortunately, inserting pdf content is not possible when editing a presentation in powerpoint for the web. Aug, 2018 ifex ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Ifosfamide definition of ifosfamide by medical dictionary. Cyclophosphamide, as a cause of hemorrhagic cystitis, was first.
Ifosfamidebased combination chemotherapy in advanced soft. We report the case of a 19yearold woman, with relapsed hodgkins lymphoma, who developed ifosfamide induced encephalopathy 16 days after the first exposure to rituximab, ifosfamide, carboplatin. The length of treatment depends on how well your body responds to treatment with. Cisplatin is a widely used antineoplastic drug with broad clinical activity. Ifosfamide injection should be administered as a slow intravenous infusion lasting a minimum of 30 minutes. Multicenter study of environmental contamination with. Knowledge and time are the 2 most valuable resources in the world that we currently live in and, now, we have many opportunities to benefit from learning quickly and easily with the help of elearning technologies. To bring you great quality, smallpdf has partnered with solid documents that offers the best conversion out there. Cancers treated with cyclophosphamide or ifosfamide include both. Guidelines for the administration of mesna with ifosfamide. Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage ww at the time of ifosfamide administration.
Dosage may be reduced, delayed or discontinued in patients with bone. This includes testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, cervical cancer, and ovarian cancer. From here, you can crop your screenshot, resize it, and position it. How to crop pictures in word, excel, and powerpoint 2010. Insert pdf file content into a powerpoint presentation powerpoint. Clinical pharmacology of ifosfamide and metabolites. Find patient medical information for ifosfamidemesna intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Always consult your healthcare provider if you have questions or concerns. I am working with a pdf that came from tableau and powerpoint and experienced the same pixalation issues as described above. Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide that is used in the treatment of several forms of cancer including lymphomas, sarcoma and advanced forms of solid organ cancer such as breast, testicular, ovarian, gastric and lung cancer. Ifosfamide has a broad spectrum of antineoplastic activity. Ifex ifosfamide dosing, indications, interactions, adverse. Ifex ifosfamide side effects, images, uses, dosage. Ifosfamide is a white crystalline powder that is soluble in water.
Ifosfamide is an alkylating agent used in the treatment of a variety of solid tumours. Insert pdf content into your presentation either as a picture that shows on your slide, or as a document that you can open during your slide show. Carcinogenesis, mutagenesis, impairment of fertility ifosfamide has been shown to be carcinogenic in rats, with female rats showing a. Ifosfamide injection 1g summary of product characteristics. Only select registry of toxic effects of chemical substances rtecs data is presented here. How to convert a powerpoint presentation to a scorm package. These may be responsible for the toxicity of the drug. Ifosfamide can cause severe neurotoxicity resulting in encephalopathy and death.
The total daily dose of mesnex is 60% of the ifosfamide dose. Dailymed ifosfamide injection, powder, for solution. Apr 25, 2008 ifosfamide is an antineoplastic agent useful in the treatment of a wide range of cancers including sarcomas, gynecologic cancers, lymphoma and testicular cancers. Clinical pharmacology ifosfamide has been shown to require metabolic activation by microsomal liver enzymes to produce biologically active metabolites. If your pdf is in a presentation format, the conversion should be no problem. Ifosfamide solution for injection drug information, side. By continuing to browse this site you are agreeing to our use of cookies. Two cases of fatal encephalopathy related to ifosfamide. Nov 09, 2018 ifosfamide can pass into breast milk and may harm a nursing baby. Continuous infusion high dose ifosfamide at 1gmm2day over 14 days is highly active and well tolerated in a heavily pretreated cohort. It should be used in combination with mesna for prophylaxis of hemorrhagic cystitis. Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage weight by weight ww at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide. Following activation in the liver, ifosfamide interferes with dna through formation of phosphotriesters and dnadna crosslinks, thereby inhibiting protein synthesis and dna synthesis. If neither of those two methods work for your needs, you can also add a pdf file into a powerpoint presentation as an action.
Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage. Methylene blue reversal of ifosfamiderelated encephalopathy. Aug 31, 2015 mesna should be used to reduce the incidence of hemorrhagic cystitis. This can last for about 24 hours after taking ifosfamide. Pdf successful treatment of ifosfamide neurotoxicity with. I am able to insert a pdf as an object into word, but the image quality is slightly blurry. Click on the thumbnail that shows your open pdf document to select it.
The information on this website is intended for informational purposes only and is not a substitute for medical advice. Ifosfamide side effects, dosage, interactions drugs. For certain toxicities, an initial dose reduction of 20% should be made, followed by an additional. Find patient medical information for ifosfamide intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Information for the patient ifosfamide injection 1 g and 2 g ifosfamide read all of this leaflet carefully before you are given this medicine because it contains important information for you. Learn more about ispring suite authoring tool and get a free trial at this tutorial shows how to convert a powerpoint presentation to a scorm package. Ifosfamide neurotoxicity and potential treatment with. Mesnex is indicated as a prophylactic agent in reducing. Oct 24, 2016 if ifosfamide is used during pregnancy, or if the patient becomes pregnant while taking this drug or after treatment, the patient should be apprised of the potential hazard to a fetus. In adult patients with inoperable locally advanced or metastatic softtissue sarcoma, do combination chemotherapy regimens containing ifosfamide have an advantage in terms of response rate, time to progression, or survival, as compared with similar regimens without ifosfamide when used as firstline therapy. Please click here for important safety information, including boxed warning regarding hepatic impairment, and click here 3 for full prescribing information. Ifosfamide is an anticancer antineoplastic or cytotoxic chemotherapy drug. A comparative effectiveness study is warranted to compare costbenefit and patient preference between 14 day and 7 day regimens.
Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. We have confirmed reports of activity in patients previously treated with ifosfamide. See actual entry in rtecs for complete information. How to insert a pdf into powerpoint online tech tips. Save money on your ifosfamide injection prescription by switching to tevas fdaapproved generic version. Mesnex tablets are given orally in a dosage equal to 40% of the ifosfamide dose 2 and 6 hours after each dose of ifosfamide. To monitor environmental contamination with cyclophosphamide. Ways to convert powerpoint into an interactive elearning module. Ifosfamide comes as powder to be mixed with liquid to be injected over at least 30 minutes intravenously into a vein by a doctor or nurse in a medical facility. Insert pdf file content into a powerpoint presentation. Ifosfamide is passed into the breast milk and may cause neutropenia, thrombocytopenia, low haemoglobin concentrations and diarrhea in children. The high incidence of this toxicity requires uroprotection with aggressive hydration, frequent bladder emptying, and the concurrent use of mesna, a uroprotective agent. Ifosfamide ifo, sold under the brand name ifex among others, is a chemotherapy medication used to treat a number of types of cancer.
Do not receive a live vaccine while using ifosfamide, or you could develop a serious infection. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Vip etoposide, ifosfamide, and cisplatin in patients with. Aprepitantifosfamideencephalopathydrug interaction. Get emergency medical help if you have signs of an allergic. Although ifosfamide has several significant toxic effects, the doselimiting toxicity is hemorrhagic cystitis. Grapefruit may interact with ifosfamide and lead to unwanted side effects. Ifosfamide investigated as a drug, mutagen, reproductive effector, and tumorigen. Review of advances in uroprotective agents for cyclophosphamide. In some cases, health care professionals may use the trade name ifex when referring to the generic drug name ifosfamide.
Mesnex mesna dosing, indications, interactions, adverse. Ifosfamide may cause neurotoxicity in 10% to 30% of treated patients. Jul 30, 2018 ifosfamide for injection ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. This process will then insert a screenshot of your open pdf document window into the powerpoint presentation. Used as an antineoplastic agent in treatment of leukemia, lymphoma, and cancers of the lung, ovary, testes, and other organs. Powerpoint 2016 tutorial inserting objects microsoft.
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